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US 10,751,407 B2Granted
PRRSV minor protein-containing recombinant viral vectors and methods of making and use thereof
AssigneeBoehringer Ingelheim Animal Health USA Inc.
InventorsTeshome Mebatsion, Aemro Kassa, Taejoong Kim
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Abstract
The present invention encompasses recombinant porcine reproductive and respiratory syndrome virus (PRRSV) vaccines or compositions. In particular, the invention encompasses recombinant adenovirus vectors encoding and expressing PRRSV gp2, gp3, gp4, gp5a, gp5 and/or E antigens, proteins, epitopes or immunogens. Such vaccines or compositions can be used to protect animals from PRRSV.
Claims19
A safe and effective immunological or vaccine composition comprising:
- a. one or more recombinant viral vectors, comprising one or more heterologous polynucleotides, encoding one or more retargeted porcine reproductive and respiratory syndrome virus (PRRSV) gp2, gp3 or gp4 antigen, or ectodomain;
- b. wherein when the retargeted gp2 is encoded, at least one of the retargeted gp3 or the retargeted gp4 antigens, is also encoded;
- and
- c. wherein the antigen or ectodomain is retargeted by the replacement of an existing cellular localization sequence of the polypeptide with a corresponding cell-surface expression determinant sequence from a heterologous gene.
1 more element
A method of eliciting a protective response in an animal against PRRSV comprising administering to the animal
- a. a recombinant Ad5-PRRSV vector expressing at least one retargeted PRRSV gp2, gp3 or gp4 antigen or ectodomain,
- wherein when the retargeted gp2 is encoded, at least one of the retargeted gp3 or the retargeted gp4 antigens, is also encoded;
- and
- wherein the antigen or ectodomain is retargeted by the replacement of an existing cellular localization sequence of the polypeptide with a corresponding cell-surface expression determinant sequence from a heterologous gene;
- and
- b. a pharmaceutically or veterinarily acceptable carrier, adjuvant, excipient or vehicle;
- and
- wherein the administration is by oro-nasal, spray, drinking water, intramuscular, or subcutaneous administration, intradermal, transdermal;
- and
- wherein the animal is a porcine.
7 more elements
Dependencies are inferred from the claim text.