Carbon monoxide-releasing molecules for therapeutic applications and methods for the preparation and use thereof

A compound according to Formula IX:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 and R2 are phenyl, each of which is optionally substituted with one or more R11 moieties, or R1 and R2 are phenyl and are taken together to form a fused tricyclic moiety which is optionally substituted with one or more R11 moieties, wherein
• R3 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
• each R4 and R5 is independently selected from the group consisting of hydrogen, substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, a protecting moiety RP, a linking moiety RL, a targeting moiety RT, and a solubility-enhancing moiety RS;
• R6 is independently selected from the group consisting of substituted or unsubstituted alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, a protecting moiety RP, a linking moiety RL, a targeting moiety RT, and a solubility-enhancing moiety RS;
• each R11 is independently selected from the group consisting of halogen, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, alkoxy, aryloxy, hydroxyl, —N(Ra)2, —SRa, —S(O)Ra, —S(O)2Ra, —OS(O)ORa, —OS(O)2ORa, —OP(ORa)2, —OP(O)HORa, —OP(ORa)2, —OP(O)(Ra)2, —P(O)(ORa)2, —ONO, —ONO2, —NO2, —(C═O)R5, —(C═O)OR6, —(C═O)NR7R8, a linking moiety RL, a targeting moiety RT, and a solubility-enhancing moiety RS;
• Ra is selected from the group consisting of hydrogen, alkyl, cycloalkyl, aryl, and heteroaryl;
• each R7, R8, R9, and R10 is independently selected from the group consisting of hydrogen, alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl;
• X is NR14 wherein R14 is hydrogen or alkyl, which is optionally substituted with halogen, haloalkyl, haloalkoxy, —OR′, or —NR′R″,
• R′ and R″ are independently selected from the group consisting of hydrogen and unsubstituted alkyl;
• or
• R′ and R″, when attached to the same nitrogen atom, are combined with the nitrogen to which they are attached to form heterocycloalkyl or heteroaryl;
• each R15 is independently selected from the group consisting of hydrogen, alkyl, cycloalkyl, heterocycloalkyl, alkenyl, alkynyl, aryl, and heteroaryl,
• or, alternatively two OR′ are taken together to form an oxo moiety;
• and subscript n is 1, 2 or 3.