Dry powder drug delivery system and methods
AssigneeMannKind Corporation
InventorsChad C. Smutney, Benoit Adamo, Brendan F. Laurenzi, P. Spencer Kinsey
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Abstract
A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, with or without a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, small organic molecules, peptides and proteins, including, hormones such as insulin and glucagon-like peptide 1 for the treatment of disease and disorders, for example, diseases and disorders, including endocrine disease such as diabetes and/or obesity.
Claims21
A medicament cartridge comprising:
- a powder container configured to include a location for a dry powder;
- a lid;
- and
- an internal volume,
- wherein the medicament cartridge is configured to include a containment configuration and a dosing configuration, wherein the lid includes a deflector or stem protruding from an undersurface facing the internal volume, wherein in the dosing configuration the deflector or stem is situated over the location for the dry powder to direct airflow entering the internal volume from a direction parallel to the lid to a substantially downward direction, to a direction substantially parallel to the lid through the location, to a direction substantially perpendicular to the lid to exit the powder container.
Dependencies are inferred from the claim text.