Devices and methods for on-line whole blood treatment
AssigneeQualigen, Inc.
InventorMichael Poirier
Life of this patent
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Abstract
A whole blood treatment device includes a first conduit, a second conduit, and a rotating or reciprocating element having a channel. The first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit. The first conduit is configured to receive whole blood, and the second conduit is configured to receive a regeneration fluid. The channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.
Claims20
A whole blood treatment device, comprising:
- a first conduit, a second conduit, and a rotating or reciprocating element having a channel;
- wherein the first and second conduits are fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the second conduit, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the second conduit;
- wherein the first conduit is configured to receive whole blood, and wherein the second conduit is configured to receive a regeneration fluid;
- and
- wherein the channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.
A method of removing a target compound from whole blood of a mammal in a whole blood treatment device, comprising:
- (a) moving the whole blood through a channel in a rotating or reciprocating element while the channel is fluidly coupled to a first conduit that contains the whole blood;
- wherein the channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood;
- (b) moving the rotating or reciprocating element in a position such that the channel is fluidly disconnected from the first conduit and fluidly connected with a second conduit;
- (c) eluting the target compound from the surface while the channel is fluidly connected with the second conduit;
- and
- (d) further moving the rotating or reciprocating element in a position such that the channel is fluidly connected with the first conduit and fluidly disconnected with the second conduit.
A whole blood treatment device, comprising:
- a first conduit, a sealing area, and a rotating or reciprocating element having a channel;
- wherein the first conduit is fluidly coupled to the rotating or reciprocating element such that the channel is fluidly continuous with the first conduit when the channel is fluidly discontinuous with the sealing area, and such that the channel is fluidly discontinuous with the first conduit when the channel is fluidly continuous with the sealing area;
- wherein the first conduit is configured to receive whole blood, and wherein the sealing area is configured to allow flow-less incubation of the whole blood in the channel when the channel is fluidly continuous with the sealing area;
- and
- wherein the channel comprises a surface that is modified with an affinity agent at a concentration effective to allow removal of a target compound from whole blood.
Dependencies are inferred from the claim text.