Modular fluid therapy system having jumpered flow paths and systems and methods for cleaning and disinfection

A system, comprising:

• a base module having at least one segment of a flow path and at least one pair of jumpered ports configured on the base module alternatively connectable to a cleaning manifold and therapy cassette, the therapy cassette containing at least one conduit and any one or more of concentrates, cartridges, sensors elements, reservoirs, filters, and vents, the cleaning manifold and therapy cassette connectable to the at least one pair of jumpered ports of the base module and defining a flow path carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration, or hemofiltration;
• wherein during hemodialysis, hemodiafiltration, or hemofiltration the base module is further connectable to at least one of a dialyzer or hemofilter;
• said cleaning manifold and therapy cassette having connections connectable to the at least one pair of jumpered ports of the base module to provide for fluid communication between the at least one segment of the flow path in the base module and a flow path defined by the cleaning manifold or therapy cassette wherein the cleaning manifold and therapy cassette are detachable from the at least one segment of the flow path;
• and
• wherein the base module connected to the cleaning manifold or therapy cassette defines a flow path configurable for carrying out in part at least one function performed during any one of hemodialysis, hemodiafiltration or hemofiltration;
• wherein the cleaning manifold cleans and disinfects the at least one segment of the flow path.