Degradable removable implant for the sustained release of an active compound
AssigneeJanssen Sciences Ireland Unlimited Company
InventorsLieven Elvire Colette Baert, Iksoo Chun, Guenter Kraus, Deborah M. Schachter, Qiang Zhang
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Abstract
A degradable, removable, pharmaceutical implant for the sustained release of one or more drugs in a subject, wherein the pharmaceutical implant is composed of a tube comprising an outer wall made of a degradable polymer completely surrounding a cavity, wherein the outer wall has a plurality of openings and wherein the cavity contains one or more sets of micro-particles, which micro-particles contain an active agent or a combination of two or more active agents, and wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.
Claims7
A degradable, removable, pharmaceutical subcutaneous implant for the sustained release of one or more drugs in a subject, comprising
- a tube that is defined by an outer wall,
- wherein the outer wall is fabricated from poly(dioxanone);
- has a plurality of openings on its surface;
- and completely surrounds a cavity,
- and wherein the cavity contains one or more sets of microparticles embedded in a hydrogel, wherein at least one set of the microparticles comprises rilpivirine and a copolymer of lactide and glycolide, and
- wherein the size of the microparticles is selected such that the majority of the microparticles cannot pass through the openings.
Dependencies are inferred from the claim text.