Antimicrobial catheters
AssigneeBoard of Regents, The University of Texas System
InventorsJoel Rosenblatt, Issam Raad
Life of this patent
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Abstract
Antimicrobial catheters and medical devices are provided. In some aspects, a low durometer aliphatic polyether polyurethane may be impregnated with a first antimicrobial agent (e.g., minocycline and rifampin) and coated with a second antimicrobial agent (e.g., chlorhexidine, gendine, or gardine). The antimicrobial catheters may display improved flexibility and resistance to kinking. Methods of producing the antimicrobial catheters are also provided.
Claims32
A medical device comprising:
- (A) a first antimicrobial polymer layer comprising an aliphatic polyether polyurethane polymer having a durometer of A or B that has been solvent impregnated with minocycline and rifampin, but has not been solvent impregnated with chlorhexidine;
- and
- (B) a second antimicrobial polymer layer formed from a polymer coating solution comprising chlorhexidine;
- wherein the polymer coating solution does not comprise minocycline or rifampin;
- and wherein the medical device is a catheter.
A medical device, comprising a polymer solvent impregnated with minocycline and rifampin, wherein the polymer has not been solvent impregnated with chlorhexidine, gendine, or gardine, and wherein a surface of the polymer is coated with a polyurethane polymer coating, wherein the polyurethane polymer coating comprises (i) a fatty acid or a guanidium compound and (ii) chlorhexidine;
- wherein the medical device is a catheter.
An antimicrobial catheter, wherein a body of the catheter comprises an A durometer aliphatic polyether polyurethane polymer, wherein the aliphatic polyether polyurethane polymer is solvent impregnated either with
- (i) minocycline and rifampin;
- or
- (ii) chlorhexidine, gendine, or gardine;
- wherein the body of the catheter is coated with an aliphatic polyether polyurethane polymer comprising chlorhexidine, gendine, or gardine.
A catheter comprising:
- a polymer tubing comprising an aliphatic polyether polyurethane polymer coating on the polymer tubing,
- wherein the polymer tubing is an aliphatic polyether polyurethane polymer or a polyurethane polymer;
- wherein the polymer tubing is solvent impregnated with minocycline and rifampin, and wherein the polymer tubing has not been solvent impregnated with chlorhexidine, gendine, or gardine;
- and
- wherein the aliphatic polyether polyurethane polymer coating comprises chlorhexidine, gendine, or gardine.
An antimicrobial catheter, wherein a body of the catheter comprises an A durometer aliphatic polyether polyurethane polymer,
- wherein the aliphatic polyether polyurethane polymer is solvent impregnated with chlorhexidine, gendine, or gardine;
- and wherein the aliphatic polyether polyurethane polymer has not been solvent impregnated with minocycline or rifampin;
- and wherein the body of the catheter is coated with an aliphatic polyether polyurethane polymer comprising minocycline and rifampin.
Dependencies are inferred from the claim text.