Methacrylated devitalized cartilage and devitalized cartilage particles
AssigneeUniversity of Kansas
InventorsMichael Detamore, Emily Beck
Life of this patent
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Abstract
An implantable composition can include methacrylated solubilized devitalized cartilage (MeSDVC) with or without devitalized cartilage (DVC) particles. These compositions can be hydrogel precursors. After implantation, the MeSDVC may be crosslinked so as to form a hydrogel. The crosslinked hydrogel can include the DVC particles. A hydrogel precursor matrix (e.g., not crosslinked) can include a crosslinkable substance that can be crosslinked into a hydrogel, where DVC particles are included in the precursor matrix. The hydrogel precursor matrix can be located in a tissue defect site, such as a hole or recess in a cartilage or bone, and then crosslinked into a hydrogel that has the DVC particles therein.
Claims20
An implantable colloidal gel composition comprising:
- methacrylated solubilized devitalized cartilage (MeSDVC) matrix, wherein the MeSDVC matrix is not crosslinked or decellularized;
- and
- devitalized cartilage (DVC) particles in the MeSDVC matrix, wherein the DVC particles are not methacrylated or decellularized or crosslinked with the MeSDVC matrix,
- wherein the MeSDVC matrix is devoid of decellularized cartilage (DCC) particles.
An implantable crosslinked hydrogel composition comprising:
- a crosslinked methacrylated solubilized devitalized cartilage (MeSDVC) matrix that is not decellularized;
- devitalized cartilage (DVC) particles in the MeSDVC matrix, wherein the DVC particles are not methacrylated or decellularized or crosslinked with the MeSDVC matrix;
- and
- water,
- wherein the MeSDVC matrix is crosslinked around the DVC particles in the form of the hydrogel,
- wherein the MeSDVC matrix is devoid of decellularized cartilage (DCC) particles.
Dependencies are inferred from the claim text.