Co-crosslinked hyaluronic acid-silk fibroin hydrogels for improving tissue graft viability and for soft tissue augmentation
AssigneeAllergan, Inc.
InventorsXiaojie Yu, Darin J. Messina, Elizabeta Pavlovic, Cunqi Cui, Kate M. Smither
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Abstract
Hydrogels comprising a macromolecular matrix and water may be used to augment soft tissue of a human being, promote or support cell or tissue viability or proliferation, create space in tissue, and for other purposes. A macromolecular matrix may comprise a hyaluronic acid component crosslinked to a silk fibroin component.
Claims26
A method of improving an aesthetic quality of an anatomic feature of a subject, the method comprising administering a hydrogel composition comprising hyaluronic acid, silk fibroin, and an ex vivo tissue to the subject, wherein the hyaluronic acid is crosslinked to the silk fibroin by a water-soluble coupling agent.
A method of augmenting soft tissue of a human being comprising:
- providing a hydrogel composition comprising hyaluronic acid and silk fibroin, wherein the hyaluronic acid is crosslinked to the silk fibroin by a water-soluble coupling agent;
- and
- mixing the hydrogel composition with an ex vivo tissue to produce a hydrogel tissue mixture.
A method of treating a soft tissue condition of a subject, the method comprising:
- administering a hydrogel composition to a site of the soft tissue condition of the subject, the hydrogel composition comprising hyaluronic acid and silk fibroin crosslinked by a water-soluble coupling agent and an ex vivo adipose tissue, wherein the administration of the hydrogel composition improves the soft tissue condition.
Dependencies are inferred from the claim text.