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US 10,744,211 B2Granted
Trifunctional and completely clearable specific targeting agents and methods thereof
AssigneeUniversity of Massachusetts
InventorsGuozheng Liu, Shuping Dou
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Abstract
The invention provides a novel trifunctional targeting construct and related compositions and methods that are useful in therapeutic, diagnostic (including imaging) of various biological and/or pathological conditions and diseases such as cancers and diabetes. The trifunctional targeting construct of the invention provides enhanced clearing step and reduced non-specific background via complete clearance of undesired antibody conjugates.
Claims3
A kit for delivering a diagnostic or therapeutic agent to a target site, the kit comprising:
- a compound:
- wherein Ab is an antibody or an antibody fragment;
- a clearing agent comprising avidin;
- and
- an effector conjugate comprising cMORF.
2 more elements
Dependencies are inferred from the claim text.