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US 10,744,209 B2Granted
Biodegradable polymeric nanoparticle conjugates and use thereof
AssigneeNew York University
InventorsAbraham Ulman, Bruce Cronstein, Linda Franks
Life of this patent
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Abstract
The present invention relates to a polymeric nanoparticle conjugate of formula (I). The present invention also relates to pharmaceutical compositions including these polymeric nanoparticle conjugates, and methods of preparation and use thereof.
Claims28
A polymeric nanoparticle conjugate,
- wherein the nanoparticle is coupled n times to a ligand having the formula:
- wherein
- is a point of coupling the ligand to the nanoparticle;
- Y is selected from the group consisting of
- Z is selected from the group consisting of —C(O)NHEt, —C(O)NHMe, —CH2OH, and
- and
- n is 1 to 500.
4 more elements
A method of treating and/or preventing arthritis in a patient in need thereof comprising:
- selecting a subject in need of treatment, and administering to the selected subject a therapeutically acceptable amount of a polymeric nanoparticle conjugate, wherein the nanoparticle is coupled n times to a ligand having the formula:
- wherein
- is a point of coupling the ligand to the nanoparticle,
- Y is selected from the group consisting of
- Z is selected from the group consisting of —C(O)NHEt, —C(O)NHMe, —CH2OH, and
- and
- n is 1 to 500.
4 more elements
A method of treating a wound in a patient in need thereof comprising:
- selecting a subject in need of treatment, and
- administering to the selected subject a therapeutically acceptable amount of a polymeric nanoparticle conjugate, wherein the nanoparticle is coupled n times to a ligand having the formula:
- wherein
- is a point of coupling the ligand to the nanoparticle;
- Y is selected from the group consisting of
- Z is selected from the group consisting of —C(O)NHEt, —C(O)NHMe, —CH2OH, and
- and
- n is 1 to 500.
5 more elements
A method of treating a dermatological condition in a patient in need thereof comprising:
- selecting a subject in need of treatment, and
- administering to the selected subject a therapeutically acceptable amount of a polymeric nanoparticle conjugate, wherein the nanoparticle is coupled n times to a ligand having the formula:
- wherein
- is a point of coupling the ligand to the nanoparticle;
- Y is selected from the group consisting of
- Z is selected from the group consisting of —C(O)NHEt, —C(O)NHMe, —CH2OH, and
- and
- n is 1 to 500.
5 more elements
A method of treating a joint to promote surgical healing comprising:
- selecting a subject in need of treatment, and
- administering to the selected subject a therapeutically acceptable amount of a polymeric nanoparticle conjugate, wherein the nanoparticle is coupled n times to a ligand having the formula:
- wherein
- is a point of coupling the ligand to the nanoparticle;
- Y is selected from the group consisting of
- Z is selected from the group consisting of —C(O)NHEt, —C(O)NHMe, —CH2OH, and
- and
- n is 1 to 500.
5 more elements
Dependencies are inferred from the claim text.