Biological complexes and methods for using same
AssigneeAcepodia, Inc.
InventorsAmy A. Twite, Ching-Wen Hsiao, Sonny Hsiao, Cheng Liu, Hong Liu
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Abstract
The disclosure provides complexes comprising targeting units, methods for their production, and methods for their use. In some embodiments, complexes comprise therapeutic agents complexed with targeting units. In some embodiments, complexes comprise cells complexed with targeting units. In view of the foregoing, there is a need for improved modalities for targeting of therapeutics, in the area of immunotherapy and others. The present disclosure addresses these needs, and provides additional advantages as well.
Claims74
A live cell comprising a surface and a population of at least about 1000 exogenous targeting units complexed to the surface, wherein an exogenous targeting unit in said population comprises a targeting moiety that is characterized in that:
- (a) it exhibits specific binding to a biological marker on a target cell;
- (b) it is not a nucleic acid;
- and
- (c) it is not produced by said live cell,
- wherein the exogenous targeting unit is complexed to the surface via an interaction between a first linker conjugated to the targeting moiety and a second linker covalently conjugated to the surface of the live cell.
Dependencies are inferred from the claim text.