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US 10,744,202 B2Granted
Sustained release eye drop formulations
AssigneeRamscor, Inc.
InventorsVernon G. Wong, Louis L. Wood
Life of this patent
Estimating the term…
Abstract
This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating topical eye drop formulations that provide sustained release of active agents.
Claims3
A method of treating an ocular condition in a subject comprising the step of:
- administering to the eye of a subject in need thereof an eye drop formulation consisting of an ophthalmologically active agent, or a derivative, analog, or pharmaceutically acceptable salt thereof, dissolved, dispersed or suspended in a tocopherol or tocotrienol selected from d, l and dl isomers of α, β, δ, ε, η tocopherol or tocotrienol, the esters of tocopherol or tocotrienol with straight and branched chain C2 to C20 aliphatic acids, and the esters of tocopherol or tocotrienol with C3 to C20 straight chain dicarboxylic acids;
- wherein the administration of a unit dose of a single eye drop has therapeutic effect for at least 4 days and said administration is repeated no more frequently than once every 4 days.
A method of treating an ocular condition in a subject comprising the step of:
- administering to the eye of a subject in need thereof an eye drop formulation consisting of an ophthalmologically active agent, or a derivative, analog, or pharmaceutically acceptable salt thereof, dissolved, dispersed or suspended in a tocopherol or tocotrienol selected from d, l and dl isomers of α, β, δ, ε, η tocopherol or tocotrienol, the esters of tocopherol or tocotrienol with straight and branched chain C2 to C20 aliphatic acids, and the esters of tocopherol or tocotrienol with C3 to C20 straight chain dicarboxylic acids;
- wherein the administration of a unit dose of a single eye drop has therapeutic effect for at least 7 days, and administration is repeated no more frequently than once every 7 days.
Dependencies are inferred from the claim text.