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US 10,744,200 B2Granted
Method for preparation of aluminium phosphate gel for application in vaccine formulations
AssigneeBiological E Limited
InventorsRavi Ganapathy, Nagireddy Gade, Manish Manohar, Vikram Madhusadan Paradkar, Mahima Datla
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Abstract
The present invention relates to an improved process for production of Aluminium phosphate (AlPhos) gel wherein the solutions of aluminium salt and alkaline phosphate salt are added to water by maintaining the pH under stirring to obtain the precipitate, followed by sterilization of the said precipitate and finally obtaining the Aluminum phosphate gel.
Claims11
A process for preparing an aluminum phosphate gel, comprising:
- admixing and stirring water and solutions of aluminum salt and alkaline phosphate salt at a pH between 3.0 and 4.0 to obtain the aluminum phosphate gel;
- and
- (ii) sterilizing the aluminum phosphate gel of step (i) by exposing the aluminum phosphate gel to a temperature in a range of 120-150° C. for a period of 30 to 90 minutes,
- wherein the aluminum phosphate gel has particles with a size distribution of d(50) in a range of 3.0 μm to 9.0 μm and a mean particle size less than 7 μm, and
- wherein the process is devoid of the steps of settling an aluminum phosphate suspension and removal of a supernatant.
2 more elements
A process for preparing an aluminum phosphate gel, comprising:
- admixing and stirring water and solutions of aluminum chloride and trisodium phosphate for 60 minutes, preferably between 35 to 55 minutes, to form the aluminum phosphate gel, and maintaining a pH of the aluminum phosphate gel between 3.0 and 4.0, preferably between 3.2 and 3.5;
- and
- (ii) sterilizing the aluminum phosphate gel of step (i) by exposing the aluminum phosphate gel to a temperature in a range of 120-150° C. for a period of 30 to 90 minutes,
- wherein the aluminum phosphate gel has particles with a size distribution of d(50) in a range of 3.0 μm to 9.0 μm and a mean particle size less than 7 μm, and
- wherein the process is devoid of the steps of settling an aluminum phosphate suspension and removal of a supernatant.
2 more elements
Dependencies are inferred from the claim text.