Immunization of avians by administration of non-replicating vectored vaccines
AssigneesAltimmune Inc., Auburn University
InventorsDe-Chu C. Tang, Kent R. Van Kampen, Haroldo Toro
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Abstract
The present invention relates generally to the fields of immunology and vaccine technology. More specifically, the invention relates to recombinant human adenovirus vectors for delivery of avian immunogens and antigens, such as avian influenza into avians. The invention also provides methods of introducing and expressing an avian immunogen in avian subjects, including avian embryos, as well as methods of eliciting an immunogenic response in avian subjects to avian immunogens.
Claims13
A pharmaceutical composition for inducing an immune response against at least one avian immunogen of interest in an avian following in ovo administration of the composition into an amnion-allantois space of an embryonated avian egg, the pharmaceutical composition comprising:
- a pharmaceutical dosage comprising a pharmaceutically acceptable carrier, excipient or diluent admixed with a recombinant human adenovirus expression vector, the recombinant human adenovirus expression vector comprising a promoter sequence operably linked to a foreign sequence encoding one or more avian antigens or immunogens of interest under the transcriptional control of the human cytomegalovirus (CMV) promoter;
- and,
- a robotic injector for administration of the composition into the amnion-allantois space of the embryonated avian egg,
- wherein the composition is configured for administration into the amnion-allantois space of an embryonated avian egg to obtain expression of the one or more avian antigens or immunogens in the avian embryo to induce the immune response in the avian.
Dependencies are inferred from the claim text.