Method for suppressing spasmodic torticollis

A method for suppressing spasmodic torticollis comprising administering to a patient in need thereof an effective amount of a polypeptide comprising:

• a) a botulinum type A neurotoxin protease domain;
• b) a botulinum type A neurotoxin translocation domain;
• and
• c) a botulinum type A neurotoxin targeting moiety that binds to a binding site on a nerve cell of the neuromuscular junction, which binding site is capable of undergoing endocytosis to be incorporated into an endosome within the nerve cell;
• wherein:
• the polypeptide comprises an amino acid sequence having at least 90% sequence identity with SEQ ID NO:
• 17, said sequence having protease, translocation, and targeting activity of a botulinum type A neurotoxin;
• and
• the translocation domain is modified by modifying the amino acid sequence located at residues 478-483, 487-499, 511-547, 561-571, 580-584, 622-635, 647-654, 673-681, 755-771, 827-840, and/or 849-863 of SEQ ID NO:
• 17, or sequences corresponding to such amino acid sequences, to include a destructive cleavage site that is cleavable by a circulatory or tissue-associated protease and not by the botulinum type A neurotoxin protease.