High osteocalcin microcrystalline hydroxyapatite for calcium supplement
AssigneeWaitaki Biosciences
InventorsCraig Lachlan McIntosh, Susan Finderup, Harold Garthwaite
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Abstract
An improved manufacturing process produces microcrystalline hydroxyapatite with sustained gradual calcium release that avoids spiking in blood calcium levels. Although the improved material did not cause significant elevation of blood calcium, it was just as effective in promoting bone mineralization as conventional calcium supplements. In addition, the material has much higher levels of bone growth factors as compared to prior hydroxyapatite products.
Claims10
A high osteocalcin microcrystalline hydroxyapatite preparation comprising 60 to 72% calcium hydroxyapatite and less than 1.5% fat, and having a particle size distribution having not more than 30% by weight of particles with a particle size smaller than 250 micron and not less than 90% by weight of particles with a particle size smaller than 850 micron, and wherein less than 70% of the calcium ion is released after 2.5 minutes of in vitro dissolution testing in 0.1M HCl stirred at 150 RPM at 37±0.5° C.
A high osteocalcin microcrystalline hydroxyapatite preparation comprising 60 to 72% calcium hydroxyapatite, less than 1.5% fat, and 24-28% protein, and having a particle size distribution having not more than 30% by weight of particles with a particle size smaller than 250 micron and not less than 90% by weight of particles with a particle size smaller than 850 micron and wherein less than 70% of the calcium ion is released after 2.5 minutes of in vitro dissolution testing in 0.1M HCl stirred at 150 RPM at 37±0.5° C.
Dependencies are inferred from the claim text.