Methods of using variants of FGF19 polypeptides for the treatment of pruritus
AssigneeNGM Biopharmaceuticals, Inc.
InventorsLei Ling, Jian Luo, Hui Tian
Life of this patent
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Abstract
Provided herein are variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FG-F19 and/or FGF21 proteins and peptide sequences (and peptidomimetics). In some embodiments, these variants and fusions modulate bile acid homeostasis, and are useful in treatment of bile acid related and associated disorders. In some embodiments, these variants and fusions have glucose lowering activity, and are useful in treatment of hyperglycemia and other disorders.
Claims52
A method of treating pruritus associated with a cholestatic liver disease in a subject in need thereof, comprising administering to the subject an effective amount of a peptide, wherein the peptide has an amino acid sequence comprising:
- (SEQ ID NO:
- 70)
- MRDSSPLVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSA
- HSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEI
- RPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEP
- EDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK.
A method of treating pruritus associated with a cholestatic liver disease in a subject in need thereof, comprising administering to the subject an effective amount of a peptide, wherein the peptide has an amino acid sequence consisting of:
- (SEQ ID NO:
- 70)
- MRDSSPLVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSA
- HSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEI
- RPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEP
- EDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK.
A method of preventing the induction or exacerbation of pruritus associated with a cholestatic liver disease in a subject being treated for the cholestatic liver disease, comprising administering to the subject an effective amount of a peptide, wherein the peptide has an amino acid sequence comprising:
- (SEQ ID NO:
- 70)
- MRDSSPLVHYGWGDPIRLRHLYTSGPHGLSSCFLRIRADGVVDCARGQSA
- HSLLEIKAVALRTVAIKGVHSVRYLCMGADGKMQGLLQYSEEDCAFEEEI
- RPDGYNVYRSEKHRLPVSLSSAKQRQLYKNRGFLPLSHFLPMLPMVPEEP
- EDLRGHLESDMFSSPLETDSMDPFGLVTGLEAVRSPSFEK.
Dependencies are inferred from the claim text.