Glycopeptide derivatives for use in the treatment and/or prevention and/or attenuation of fibrosis diseases
AssigneeTfchem
InventorsGéraldine Deliencourt-Godefroy, Jocelyne Legoedec
Life of this patent
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Abstract
The present invention relates to a compound of the following formula (I), as well as to a pharmaceutical composition comprising at least one compound of following formula (I) and at least one pharmaceutically acceptable excipient, for use in the treatment and/or prevention and/or attenuation of fibrosis diseases, in particular excessive scars such as keloids or hypertrophic scars.
Claims21
A method of treating and/or preventing and/or attenuating a fibrosis disease, comprising the administration to a person in need thereof of an effective amount of a compound of following formula (I):
- or a salt thereof, a solvate, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions,
- in which:
- n represents an integer from 1 to 6,
- m represents 0 or 1,
- p represents 0 or 1
- R represents H, F, CH3, CH2F, or CH2OH,
- R1, R2 and R3 represent, independently from one another, H, F, or OH,
- R4 represents a hydrogen, a halogen, or OH, and
- R6 and R7 represent, independently from each other, a hydrogen, a (C1-C6)alkyl, an aryl, or an aryl-(C1-C6)alkyl.
A method of treating and/or preventing and/or attenuating a fibrosis disease, comprising the administration to a person in need thereof of an effective amount of a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and at least one compound of following formula (I):
- or a salt thereof, a solvate, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions,
- in which:
- n represents an integer from 1 to 6,
- m represents 0 or 1,
- p represents 0 or 1
- R represents H, F, CH3, CH2F, or CH2OH,
- R1, R2 and R3 represent, independently from one another, H, F, or OH,
- R4 represents a hydrogen, a halogen, or OH, and
- R6 and R7 represent, independently from each other, a hydrogen, a (C1-C6)alkyl, an aryl, or an aryl-(C1-C6)alkyl.
A dressing comprising a pad, compress or sponge impregnated with a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and at least one compound of following formula (I):
- or a salt thereof, a solvate, a tautomer, a stereoisomer or a mixture of stereoisomers in any proportions,
- in which:
- n represents an integer from 1 to 6,
- m represents 0 or 1,
- p represents 0 or 1
- R represents H, F, CH3, CH2F, or CH2OH,
- R1, R2 and R3 represent, independently from one another, H, F, or OH,
- R4 represents a hydrogen, a halogen, or OH, and
- R6 and R7 represent, independently from each other, a hydrogen, a (C1-C6)alkyl, an aryl, or an aryl-(C1-C6)alkyl.
Dependencies are inferred from the claim text.