Method for treatment of inflammatory skin disorders with inhibitors of IL-36 proteolytic processing

A method for the treatment of at least one inflammatory skin disorder selected from the group consisting of plaque psoriasis, guttate psoriasis, palmoplantar psoriasis, generalized pustular psoriasis, flexural psoriasis, inverse psoriasis, erythrodermic psoriasis, psoriasis vulgaris, and arthritic psoriasis, in a subject in need thereof, the method comprising:

• administering to the subject an effective amount of at least one peptide, or a combination thereof, selected from the group consisting of:
• a) a peptide consisting of 3 to 8 consecutive amino acids of SEQ ID NO:1, wherein the 3 to 8 consecutive amino acids comprises:
• Asp-Pro-Gln-Arg (NPQR);
• Pro-Gln-Arg (PQR);
• Gln-Arg-Glu-Ala (QREA);
• Asp-Pro-Gln-Arg (NPQR-CMK);
• Pro-Gln-Arg (PQR-CMK);
• or
• Gln-Arg-Glu-Ala (QREA-CMK);
• b) a peptide consisting of 3 to 8 consecutive amino acids of SEQ ID NO:2, wherein the 3 to 8 consecutive amino acids comprises:
• Arg-Ala-Val (RAV);
• Gly-Arg-Ala-Val (GRAV);
• Ala-Val-Tyr-Gln (AVYQ);
• Arg-Ala-Val (RAV-CMK);
• Gly-Arg-Ala-Val (GRAV-CMK);
• or
• Ala-Val-Tyr-Gln (AVYQ-CMK);
• c) a peptide consisting of 3 to 8 consecutive amino acids of SEQ ID NO:28, wherein the 3 to 8 consecutive amino acids comprises:
• Lys-Ala-Leu (KAL);
• or
• Lys-Ala-Leu (KAL-CMK);
• and
• d) a peptide selected from the group consisting of:
• Ala-Leu-Ala (ALA);
• Met-Ala-Leu-Ala (MALA);
• Ala-Leu-Ala (ALA-CMK);
• and
• Met-Ala-Leu-Ala (MALA-CMK).