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AssigneeLTS Lohmann Therapie-Systeme AG
InventorsMichael Li, Markus Krumme
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An edible orally disintegrating tablet dosage form containing an unpalatable acidic active pharmaceutical ingredient, particularly ketoprofen, and an ion exchange resin as a primary taste masking agent, along with an optional alkaline agent and further optionally containing one or more secondary taste masking agents is provided. The edible orally disintegrating tablet dosage matrix is formed from at least one water soluble or miscible polymer(s). The optional secondary taste masking ingredients include one or more of flavoring agent(s), sweetener(s), cooling sensation agent(s), and taste receptor blocker(s). The inventive dosages minimize or completely mask the bitterness, burning sensation and throat irritation associated with many acidic active pharmaceutical ingredients. Methods for preparing the inventive edible oral film strip dosage forms are disclosed, as well as their method of administration.
An edible orally disintegrating tablet comprising at least one water dispersible or water disintegrable polymer, an acidic active pharmaceutical ingredient and at least one anion exchange resin as a primary taste masking agent, wherein said tablet further comprises an edible alkaline agent in an amount that is less than or equal to the amount of active ingredient;
Dependencies are inferred from the claim text.