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US 10,744,171 B2Granted
Sequential anti-cancer treatment
AssigneeDuke University
InventorsDarell D. Bigner, Matthias Gromeier, Annick Desjardins, Henry S. Friedman, Allan H. Friedman, John H. Sampson
Life of this patent
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Abstract
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Sequential treatment with the virus construct followed by chemotherapy drugs increases the anti-tumor effect. Tumors of different types are susceptible to the combination treatment, including but not limited to melanoma, glioblastoma, renal cell carcinoma, prostate cancer, breast cancer, lung cancer, medulloblastoma, and colorectal cancer.
Claims24
A method of treating a progressing tumor in a patient, comprising:
- administering to the patient with a progressing tumor a chimeric poliovirus construct comprising a Sabin type I strain of poliovirus with a human rhinovirus 2 (HRV2) internal ribosome entry site (IRES) in said poliovirus' 5′ untranslated region between said poliovirus' cloverleaf and said poliovirus' open reading frame, wherein the patient has been previously treated with a lymphodepleting chemotherapeutic agent;
- and
- administering a lymphodepleting chemotherapeutic agent to the patient when growth of the tumor progresses after the chimeric poliovirus construct is administered.
Dependencies are inferred from the claim text.