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US 10,744,166 B2Granted
Compositions comprising bacterial strains
Assignee4D Pharma Research Limited
InventorsImke Elisabeth Mulder, Amy Beth Holt, Seanin Marie McCluskey, Grainne Clare Lennon, Suaad Ahmed
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Abstract
The invention provides compositions comprising bacterial strains for treating and preventing inflammatory and autoimmune diseases.
Claims17
A pharmaceutical composition that comprises:
- from about 1×103 to about 1×1011 colony forming units (CFU)/g of a single therapeutically active bacterial strain, with respect to a total weight of said pharmaceutical composition, wherein said single therapeutically active bacterial strain is a bacterial strain of the species Erysipelatoclostridium ramosum, wherein the single therapeutically active bacterial strain is a spore-forming bacterial strain, and wherein said single therapeutically active bacterial strain is lyophilized;
- and
- a pharmaceutically acceptable excipient, diluent, or carrier.
A method of treating inflammation characterized by an elevated level of an IL-17 cytokine in a subject in need thereof, comprising administering to said subject a pharmaceutical composition that comprises:
- a therapeutically effective amount of a therapeutically active bacterial strain, wherein said therapeutically effective bacterial strain is a bacterial strain of the species Erysipelatoclostridium ramosum, and a pharmaceutically acceptable excipient, diluent, or carrier,
- wherein said therapeutically active bacterial strain is a spore-forming bacterial strain, wherein said therapeutically active bacterial strain is lyophilized;
- and
- wherein said administering is sufficient to reduce said elevated level of said IL-17 cytokine relative to a level of said IL-17 cytokine prior to said administering, thereby treating said inflammation.
1 more element
Dependencies are inferred from the claim text.