Repair and regeneration of ocular tissue using postpartum-derived cells
AssigneeDePuy Synthes Products, Inc.
InventorsSanjay Mistry, Darin J. Messina
Life of this patent
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Abstract
Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.
Claims16
A method for promoting axonal regeneration in an optic nerve in a patient having optic nerve trauma comprising administering to the optic nerve isolated umbilicus-derived cells isolated from human umbilical cord tissue substantially free of blood, in an amount effective to promote axonal regeneration, wherein the isolated umbilicus-derived cells are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a neural phenotype, maintain a normal karyotype upon passaging and lack production of CD117.
A method for preserving the outer nuclear layer of a retina in a patient with retinal degeneration comprising administering to the interior of the patient's eye isolated umbilicus-derived cells isolated from human umbilical cord tissue substantially free of blood, in an amount effective to preserve the outer nuclear layer, wherein the isolated umbilicus-derived cells are capable of self-renewal and expansion in culture, have the potential to differentiate into cells of at least a neural phenotype, maintain a normal karyotype upon passaging and lack production of CD117.
Dependencies are inferred from the claim text.