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US 10,744,161 B2Granted
Vivo iron labeling of stem cells and tracking these labeled stem cells after their transplantation
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorHeike E. Daldrup-Link
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Abstract
Intravenous ferumoxytol is used to effectively label mesenchymal stem cells (MSCs) in vivo and is used for in vivo tracking of stem cell transplants with magnetic resonance (MR) imaging. The method eliminates risk of contamination and biologic alteration of MSCs associated with ex-vivo-labeling procedures.
Claims9
A method for in vivo and noninvasive monitoring of stem cell implants, comprising:
- (a) intravenously injecting iron oxide nanoparticles into a subject to achieve in vivo phagocytotic iron labeling of stem cells;
- (b) harvesting from bone marrow of said subject the in vivo iron labeled stem cells;
- (c) directly after harvesting, without ex vivo iron labeling of stem cells, transplanting the harvested in vivo iron labeled stem cells into the same subject;
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- (d) monitoring in vivo and noninvasively the transplanted in vivo iron labeled stem cells using magnetic resonance imaging.
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