Anti-MICA antigen binding fragments, fusion molecules, cells which express and methods of using

A MICA binding molecule that specifically binds to major histocompatibility complex class I chain-related gene A (MICA) selected from an antibody and an antigen binding fragment, wherein the MICA binding molecule comprises:

• (i) variable heavy (“VH”) CDR1, 2 and 3 polypeptides of SEQ ID NO:35, 36 and 22 respectively;
• and variable light (“VL”) CDRs of SEQ ID NO:26, 28 and 37 respectively;
• and wherein:
• the antigen binding fragment comprises an antigen binding domain, a single chain variable fragment (scFv), an scFv-Fc, or an antibody fragment selected from F(ab′)2, F(ab)2, F(ab′), F(ab), Fv, and dsFv;
• and
• the antigen binding fragment is optionally comprised within an (scFv)2, a di-scFv, a bi-scFv, a diabody, a bivalent single chain variable fragment, a trivalent single chain variable fragment, a tetravalent single chain variable fragment, a kappa-lambda body, a chimeric antigen receptor (CAR), a bi-specific T-cell engager, a dual affinity retargeting reagent, or other fusion protein.