Back to results
US 10,744,156 B2Granted
Intradialytic use of sodium thiosulfate
AssigneeHope Medical Enterprises, Inc.
InventorCraig Sherman
Life of this patent
Estimating the term…
Abstract
Provided herein are methods for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium thiosulfate to a subject undergoing hemodialysis.
Claims18
A method for maintaining physiological levels of thiosulfate in a subject undergoing hemodialysis;
- preventing myocardial infarction in a subject undergoing dialysis;
- preventing sudden cardiac death in a subject undergoing dialysis;
- preventing stroke in a subject undergoing dialysis;
- preventing cardiovascular disease that is characterized by tissue ischemia in a subject undergoing dialysis;
- preventing high blood pressure in a subject undergoing dialysis;
- preventing pulmonary hypertension in a subject undergoing dialysis;
- preventing renal hypertension in a subject undergoing dialysis;
- or preventing atherosclerosis in a subject undergoing dialysis, comprising intradialytically contacting said subject's blood with a dialyzer membrane that is also in contact with a thiosulfate-spiked dialysate, wherein an aqueous solution comprising sodium thiosulfate is added to an unspiked dialysate as the unspiked dialysate flows from a dialysis machine to a dialyzer membrane, wherein said unspiked dialysate comprises a mixture of water, an acid concentrate solution, and a bicarbonate concentrate solution, and wherein said thiosulfate-spiked dialysate has a pH greater than about 7.0, and wherein the concentration of thiosulfate in said thiosulfate-spiked dialysate is no more than about 10 micromolar.
5 more elements
Dependencies are inferred from the claim text.