Galactose-pronged polysaccharides in a formulation for antifibrotic therapies

A method comprising the steps of:

• Administering parenterally to a subject having a disease selected from the group consisting of chronic kidney disease associated with the development of fibrosis, established kidney fibrosis and kidney cirrhosis, an effective dose of the galacto-rhamnogalacturonan compound in an acceptable pharmaceutical carrier that results in at least one of the following:
• Inhibition or slowing down of the progression of the fibrosis or cirrhosis or reduction of established fibrosis or cirrhosis;
• or reduction in the medical consequences of fibrosis or cirrhosis;
• wherein the modified galacto-rhamnogalacturonan compound is a branched heteropolymer having a backbone of alternating α-1,2 linked rhamnose and α-1,4-linked GalA residues that carries neutral side-chains of predominantly 1,4-β-D-galactose and/or 1,5-α-L-arabinose residues attached to the rhamnose residues of the backbone and wherein the galacto-rhamnogalacturonan compound is modified by demethoxylation, deacetylation or depolymerization, and wherein the modified galacto-rhamnogalacturonan compound has a molecular weight between 20 kDa and 70 kDa.