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US 10,744,144 B2Granted
Pharmaceutical formulation
AssigneeSemnur Pharmaceuticals, Inc.
InventorMahendra G. Shah
Life of this patent
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Abstract
Disclosed are aqueous pharmaceutical compositions which provide sustained released delivery of corticosteroid compounds. The pharmaceutical composition comprises an insoluble corticosteroid; a soluble corticosteroid; and at least one viscosity enhancing agent. Also provided are methods for using the pharmaceutical compositions in an epidural injection, intra-articular injection, intra-lesional injection, or an intra-ocular injection.
Claims38
An aqueous pharmaceutical composition comprising
- an insoluble corticosteroid;
- a soluble corticosteroid;
- and
- at least one viscosity enhancing agent;
- wherein the at least one viscosity enhancing agent is sodium hyaluronate or hyaluronic acid and the insoluble corticosteroid and soluble corticosteroid are selected from the group consisting of salts and esters of dexamethasone,
- wherein the molecular weight of at least one viscosity enhancing agent is between 1.0 MDa and 2.5 MDa;
- and
- wherein the concentration of the at least one viscosity enhancing agent is between 1.0% w/v and 1.5% w/v.
5 more elements
Dependencies are inferred from the claim text.