Liquisolid tablet containing combined dose of tadalafil and dapoxetine
AssigneeKing Abdulaziz University
InventorsKhalid M. El-Say, Fayez O. Alotaibi, Nabil A. Alhakamy, Abdelsattar M. Omar
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Abstract
A liquisolid tablet formulation, comprising a microcrystalline cellulose carrier; a silica coating; a crosslinked polyvinylpyrrolidone (PVP) superdisintegrant; a solvent comprising polyethylene glycol (PEG) 200 and caprylocaproyl macrogol-8 glycerides; tadalafil; and dapoxetine, wherein the liquid load factor of the formulation is 0.2-0.4 is provided. Methods of making the liquisolid tablet and methods of using the formulation for the treatment of male sexual dysfunction are also provided.
Claims13
A liquisolid tablet formulation, comprising
- a microcrystalline cellulose carrier;
- a silica coating;
- a crosslinked polyvinylpyrrolidone (PVP) superdisintegrant;
- tadalafil dissolved in a first solvent comprising polyethylene glycol (PEG) 200;
- and
- dapoxetine dissolved in a second solvent comprising caprylocaproyl macrogol-8 glycerides,
- wherein the liquid load factor of the formulation is 0.2-0.4.
A method of preparing a liquisolid tablet formulation, comprising
- dissolving tadalafil in a solvent comprising PEG 200;
- dissolving dapoxetine in a solvent comprising caprylocaproyl macrogol-8 glycerides;
- mixing the dissolved tadalafil and the dissolved dapoxetine to form a combined solution;
- adding a microcrystalline cellulose carrier, a crosslinked polyvinylpyrrolidone (PVP) superdisintegrant, and silica coating to the combined solution to form a dry mixture;
- and
- compressing the dry mixture to form a liquisolid tablet.
Dependencies are inferred from the claim text.