Pharmaceutical composition for cancer immunotherapy and/or immunological activation containing diamino heterocyclic carboxamide compound as active ingredient
AssigneeAstellas Pharma Inc.
InventorsTomohiro Eguchi, Taku Yoshida, Ruriko Kado
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Abstract
6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide or a pharmaceutically acceptable salt thereof has an excellent immunological activation effect, and a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof as an active ingredient is expected to be used as a pharmaceutical composition for cancer immunotherapy and/or as a pharmaceutical composition for immunological activation.
Claims4
A method for immunological activation, comprising administering, to a subject in need thereof, a therapeutically effective amount of 6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazine-2-carboxamide or a pharmaceutically acceptable salt thereof in combination with a monoclonal antibody inhibiting binding of PD-1 and PD-L1,
- wherein said monoclonal antibody inhibiting the binding of PD-1 and PD-L1 is selected from the group consisting of nivolumab, pembrolizumab, atezolizumab, pidilizumab, avelumab, and durvalumab.
Dependencies are inferred from the claim text.