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US 10,744,133 B2Granted
Compound for anti-cancer therapy that acts by targeting GOF mutant p53 and stimulates p73 to restore the p53 pathway signaling
AssigneeThe Penn State Research Foundation
InventorsWafik S. El-Deiry, Shengliang Zhang
Life of this patent
Estimating the term…
Abstract
The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or preventing cancer in a subject, comprising the step of administering to the subject the compositions contemplated within the invention.
Claims23
A method of treating cancer in a subject, wherein the cancer is associated with a p53 gain of function (GOF) mutation,
- further wherein the cancer is selected from the group consisting of carcinomas, sarcomas, lymphomas, leukemia, blastomas, germ cell cancers, breast cancer, lung cancer, pancreatic cancer, stomach cancer, bone cancer, ovarian cancer, prostate cancer, bladder cancer, cervical cancer, colon cancer, skin cancer, gliomas, esophageal cancer, oral cancer, gallbladder cancer, liver cancer, testicular cancer, uterine cancer, thyroid cancer, and throat cancer.
Dependencies are inferred from the claim text.