Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan

A method of treating metastatic adenocarcinoma of the pancreas in a human patient who has previously been treated with gemcitabine, comprising intravenously administering an antineoplastic therapy to the patient once every two weeks, the therapy consisting of

• i) irinotecan sucrose octasulfate salt liposome injection in a dose providing the equivalent of 70 mg/m2 of irinotecan free base,
• ii) 200 mg/m2 of the (l) form of leucovorin or 400 mg/m2 of the (l+d) racemic form of leucovorin, and
• iii) 2400 mg/m2 of 5-fluorouracil.