6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof

A compound, or a pharmaceutically acceptable salt thereof, of Formula I:

• wherein:
• R1, R2, R4, and R5 are H;
• R3 is a 5-membered heteroaryl optionally substituted with 1-4 R36;
• R6 is selected from the group consisting of
• and
• R7 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R44 and -carbocyclyl optionally substituted with 1-12 R45;
• R15 is selected from the group consisting of -heterocyclyl optionally substituted with 1-10 R44 and -carbocyclyl optionally substituted with 1-12 R45;
• each R36 is independently selected from the group consisting of H, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), and unsubstituted —(C1-5 haloalkyl);
• each R43 is independently halide;
• each R44 is independently selected from the group consisting of unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), unsubstituted —(C1-5 haloalkyl), and -carbocyclyl optionally substituted with 1-12 R43;
• and
• each R45 is independently halide.