US 10,744,119 B1Granted

Inhibitors of the malarial GST

AssigneeUniversity of Puerto Rico

InventorsAdelfa E. Serrano-Brizuela, Emilee E. Colón-Lorenzo, Jürgen Bosh, Daisy Colón-López

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Abstract

A compound to inhibit a glutathione S-transferase (GST) enzyme activity having formula (I). The compound having formula (I) is an antimalarial compound that inhibits the growth of the Plasmodium spp parasites. The compound of the present invention inhibits the growth of a malarial parasite by 50%.

Claims6

Dependent claims

A method for treating malaria in a mammal, the method comprising:

administering to a mammal a compound having formula (I):

Dependencies are inferred from the claim text.

Facts

Application: 14/970,515Filed 15 Dec 2015 · us provisional application
Priority: 15 Dec 2014
Granted: 18 Aug 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/4184
1,3-Diazoles: condensed with carbocyclic rings, e.g. benzimidazoles
A61K 31/166
Having aromatic rings, e.g. colchicine, atenolol, progabide: having the carbon of a carboxamide group directly attached to the aromatic ring, e.g.…
A61K 31/426
Thiazoles: 1,3-Thiazoles
A61K 31/4375
Ortho- or peri-condensed with heterocyclic ring systems: the heterocyclic ring system containing a six-membered ring having nitrogen as a ring…

Family

Application62/091,637Us provisional application · filed 15 Dec 2014
US 10,744,119 B1This patent

From the US filing history. Foreign family members aren’t listed.

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