Derivatives of korormicin useful as antibiotics
OwnerPavel Dibrov, Elena Dibrov +1inventors
InventorsPavel Dibrov, Elena Dibrov, Grant Pierce
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Abstract
An antibiotic compound of formula (III): or a salt or stereoisomer thereof; wherein R1-R3 and R5-R10 are independently selected from the group consisting of H, alkyl group, substituted alkyl group, halogen, OH, NH2 and SH; R4 is H, alkyl group or substituted alkyl group; X1-X2 are independently selected from the group consisting of ═O, ═S, NH, H, alkyl, halogen, OH, SH and NH2; W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms; and Z is a neutral or positively charged organic group. The compounds are useful in treating bacterial diseases.
Claims21
An antibiotic compound of formula (III):
- or a salt or stereoisomer thereof;
- wherein R1-R3 and R5-R10 are independently selected from the group consisting of H, alkyl group, halogen, OH, NH2 and SH;
- R4 is H or alkyl group;
- X1-X2 are independently selected from the group consisting of ═O, ═S, ═NH, H, alkyl, halogen, OH, SH and NH2;
- W is a saturated acyclic hydrocarbon chain of 1 to 15 carbon atoms consisting only of hydrogen and carbon atoms;
- and
- Z is CH3.
Dependencies are inferred from the claim text.