Reversibly protected thiolated electrophilic fatty acids as prodrugs
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsBruce A. Freeman, Nicholas Khoo, Francisco Jose Schopfer, Steven Woodcock
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Abstract
Various embodiments of this invention are directed to pharmaceutical compositions and methods for treating disease. The compositions of such embodiments include thiolated nitro fatty acids. The methods of various embodiments include administering an effective amount of any of these pharmaceutical compositions to a patient in need of treatment.
Claims17
A composition comprising an effective amount of a thiolated nitro fatty acid of the formula:
- wherein x is 1 to 5;
- and q, m, p and t are, independently, 1 to 10;
- and
- a pharmaceutically acceptable excipient.
A method for treating an inflammatory condition, obesity, metabolic syndrome, acute kidney disease, chronic kidney disease, atherogenesis, adipogenesis, neointimal proliferation, kidney I/R and xenobiotic injury, focal myocardial I/R injury, Ang II-induced systemic hypertension, pulmonary hypertension, cardiac and pulmonary fibrosis, inflammatory bowel disease, nociception, stroke, motor neuron degeneration, diabetes, asthma, or COPD comprising administering to a subject in need thereof a thiolated nitro fatty acid of the formula:
- wherein x is 1 to 5;
- and q, m, p and t are, independently, 1 to 10;
- and
- a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.