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US 10,744,096 B2Granted
Pharmaceutical soft gelatin capsule dosage form with modified guar gum
AssigneeAllergan Pharmaceuticals International Limited
InventorsBrendan Muldoon, Ryan Gerald Loughlin, Gerarde Sweeney, Emma Karen Boyd
Life of this patent
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Abstract
A pharmaceutical soft gelatin capsule dosage form that includes (a) a shell that includes gelatin; and (b) a fill that includes at least one active ingredient, one or more polyethylene glycol, and a modified guar gum. The pharmaceutical soft gelatin capsule dosage form maintains its shell integrity (hardness) and fill viscosity after storage.
Claims17
A pharmaceutical soft gelatin capsule dosage form comprising:
- a shell comprising gelatin and a plasticizer;
- and
- a fill encapsulated by the shell, the fill containing less than 1.0% w/w water prior to encapsulation and further comprising at least one pharmaceutically active ingredient, one or more polyethylene glycol, and hydroxypropyl guar gum;
- wherein the pharmaceutical soft gelatin capsule dosage form is for vaginal administration;
- and
- wherein the fill after encapsulation comprises about 6.0 to 11.0% w/w water.
3 more elements
A pharmaceutical soft gelatin capsule dosage form comprising:
- a shell comprising gelatin and a plasticizer;
- and
- a fill encapsulated by the shell, the fill containing less than 1.0% w/w water prior to encapsulation and further comprising at least one pharmaceutically active ingredient, one or more polyethylene glycol, and hydroxypropyl guar gum;
- wherein the pharmaceutical soft gelatin capsule dosage form is for vaginal administration;
- and
- wherein the pharmaceutical soft gelatin capsule dosage form maintains hardness for at least 15 months when stored at 25° C. and a relative humidity of 60%.
3 more elements
Dependencies are inferred from the claim text.