Temperature-sensitive composite and method for preparing same
AssigneeKorea University Research and Business Foundation, Sejong Campus
InventorSoon Hong Yuk
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Abstract
The present invention relates to a temperature-sensitive composite and a method for preparing the same. The temperature-sensitive composite according to the present invention is maintained in a liquid state at room temperature and solidified at the time of delivery in the body, and shows remarkably excellent improvement in mechanical properties compared with an existing temperature-sensitive polymer composite, and as a result, the temperature-sensitive composite can promote the stability of a drug delivery system in the body and the sustainment of drug release.
Claims2
A temperature-sensitive composite comprising:
- 1) nanoparticles including a poorly-soluble drug-loaded with a PEO-PPO-PEO copolymer, the PEO-PPO-PEO copolymer exhibits a temperature-induced phase transition and is selected from the group consisting of Pluronic F-127, Pluronic F-188, Pluronic F-237, Pluronic F-338, Pluronic F-407, and combinations thereof;
- and
- 2) a diluent capable of controlling viscosity;
- the diluent is nanoparticles including a water-soluble drug-loaded with a biocompatible and water-soluble polymer, the biocompatible and water-soluble polymer is selected from the group consisting of Pluronic F-68, and polyvinyl acetate,
- wherein the temperature-sensitive composite is maintained in a sol state at room temperature, is gelated at the time of delivery in the body, and sustains drug release;
- wherein the poorly-soluble drug is selected from the group consisting of docetaxel and naproxen;
- wherein the water-soluble drug is doxorubicin.
A method for preparing a temperature-sensitive composite comprising:
- preparing nanoparticles including a poorly-soluble drug-loaded with a PEO-PPO-PEO copolymer, the PEO-PPO-PEO copolymer exhibits a temperature-induced phase transition and is selected from the group consisting of Pluronic F-127, Pluronic F-188, Pluronic F-237, Pluronic F-338, Pluronic F-407, and combinations thereof;
- and
- mixing the nanoparticles with a diluents capable of controlling viscosity, the diluent is nanoparticles including a water-soluble drug-loaded with a biocompatible and water-soluble polymer, the biocompatible and water-soluble polymer is selected from the group consisting of Pluronic F-68, and polyvinyl acetate;
- wherein the temperature-sensitive composite is maintained in a sol state at room temperature, is gelated at the time of delivery in the body and sustains drug release;
- wherein the poorly-soluble drug is selected from the group consisting of docetaxel and naproxen;
- wherein the water-soluble drug is doxorubicin.
Dependencies are inferred from the claim text.