Compositions and methods for topical application and transdermal delivery of botulinum toxins
AssigneeRevance Therapeutics, Inc.
InventorsMichael D Dake, Jacob M Waugh
Life of this patent
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Abstract
Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.
Claims20
A method of treating hyperhidrosis in a patient in need thereof, said method comprising:
- topically administering to an affected area of the patient in need of treatment, a pharmaceutically acceptable composition comprising:
- botulinum toxin,
- a carrier comprising a positively charged polymeric backbone with positively charged efficiency groups covalently attached thereto;
- a poloxamer;
- and
- a dermatologically or pharmaceutically acceptable excipient, diluent, or medium;
- wherein the botulinum toxin is non-covalently associated with the positively charged polymeric backbone;
- and wherein the carrier comprising the positively charged backbone is the sole necessary agent for non-covalently associating with the botulinum toxin and delivering the botulinum toxin to the affected area so as to treat the hyperhidrosis in said patient.
Dependencies are inferred from the claim text.