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US 10,743,996 B2Granted
Amnion putty for cartilage repair
OwnerRobert L. Bundyinventor
Life of this patent
Estimating the term…
Abstract
There are disclosed compositions for achieving reverse phase characteristics, methods of preparation thereof, and the use of amniotic tissue for cartilage repair. In an embodiment, a biocompatible articular tissue repair composition may have a therapeutic material and a carrier configured for achieving reverse phase characteristics, and methods for using the composition. In various embodiments, the therapeutic material may be amniotic tissue. In various embodiments, the carrier may be a poloxamer such as poloxamer 407. Other embodiments are also disclosed.
Claims13
A biocompatible articular cartilage tissue repair composition, comprising:
- components of amniotic tissue, and the components of the amniotic tissue including growth factors configured to regenerate cartilage at a cartilage defect site in an articulating joint containing synovial fluid;
- and
- a reverse phase mixture of poloxamer and a liquid, the reverse phase mixture configured as a carrier of the amniotic tissue, and the carrier configured to resorb after a first period of time at the cartilage defect site while leaving the amniotic tissue at the cartilage defect site to allow ingrowth of the amniotic tissue into the cartilage defect site;
- wherein the composition exhibits reverse phase behavior, wherein the composition is non-liquid at ambient and body temperatures, and wherein the composition supports the amniotic tissue with the carrier at the cartilage defect site for the first period of time for the carrier to resorb, and wherein the composition further supports the amniotic tissue with ingrowth during and subsequent to the first period of time so as to maintain the growth factors configured to regenerate cartilage at the cartilage defect site for a second period of time, the second period of time being longer than the first period of time, as the amniotic tissue is kept in place within the articulating joint containing synovial fluid;
- and
- wherein the components of the amniotic tissue include at least one of cut amniotic tissue, blended amniotic tissue, chopped amniotic tissue, and mixed amniotic tissue.
3 more elements
A biocompatible articular cartilage tissue repair composition, comprising:
- therapeutic material for treating a cartilage defect site, the therapeutic material including components of amniotic tissue;
- and
- a reverse phase mixture of poloxamer and a liquid, the reverse phase mixture configured as a carrier of the components of the amniotic tissue, and the carrier configured to resorb after a first period of time at the cartilage defect site while leaving the components of the amniotic tissue at the cartilage defect site to allow ingrowth of the components the amniotic tissue into the cartilage defect site;
- wherein the composition exhibits reverse phase behavior and is non-liquid at ambient and body temperatures, wherein the composition is non-liquid at ambient and body temperatures, and wherein the composition supports the components of the amniotic tissue with the carrier at the cartilage defect site for the first period of time for the carrier to resorb, and wherein the composition further supports the components of the amniotic tissue with ingrowth during and subsequent to the first period of time so as to regenerate cartilage at the cartilage defect site for a second period of time, the second period of time being longer than the first period of time, as the components of the amniotic tissue are kept in place within an articulating joint containing synovial fluid and
- wherein the components of the amniotic tissue include at least one of cut amniotic tissue, blended amniotic tissue, chopped amniotic tissue, and mixed amniotic tissue.
2 more elements
A biocompatible articular cartilage tissue repair composition, comprising:
- components of tissue, and the components of tissue including growth factors configured to regenerate cartilage at a cartilage defect site in an articulating joint containing synovial fluid;
- and
- a reverse phase mixture of poloxamer and a liquid, the reverse phase mixture configured as a carrier of the tissue, and the carrier configured to resorb after a first period of time at the cartilage defect site while leaving the components of tissue at the cartilage defect site to allow ingrowth of the components of tissue into the cartilage defect site;
- wherein the composition exhibits reverse phase, wherein the composition is non-liquid at ambient and body temperatures, and wherein the composition supports the components of tissue with the carrier at the cartilage defect site for the first period of time for the carrier to resorb, and wherein the composition further supports the components of tissue with ingrowth during and subsequent to the first period of time so as to maintain the growth factors configured to regenerate cartilage at the cartilage defect site for a second period of time, the second period of time being longer than the first period of time, as the components of tissue is kept in place within the articulating joint containing synovial fluid;
- wherein the components of the tissue include at least one of cut amniotic tissue, blended amniotic tissue, chopped amniotic tissue, and mixed amniotic tissue.
2 more elements
Dependencies are inferred from the claim text.