System and methods for processing analyte sensor data for sensor calibration

A method for calibrating data from a transcutaneous electrochemical glucose sensor, the method comprising:

• receiving sensor data from the transcutaneous electrochemical glucose sensor after at least a portion of the transcutaneous electrochemical glucose sensor is inserted in a host, wherein the sensor data is indicative of a glucose concentration in the host;
• and
• calibrating, using a processor, the sensor data received from the transcutaneous electrochemical glucose sensor,
• wherein the calibrating comprises retrieving and using calibration information derived at least in part from each of in vitro testing, in vivo testing, and a relationship between in vitro sensitivity and in vivo sensitivity derived therefrom;
• and,
• wherein the calibrating comprises not using reference glucose concentration values obtained after insertion of the at least a portion of the transcutaneous electrochemical glucose sensor into a host.

A glucose monitoring system comprising:

• a transcutaneous electrochemical glucose sensor having an in vivo portion and an ex vivo portion;
• a memory storing calibration information derived at least in part from an empirically derived relationship between in vitro sensitivity and in vivo sensitivity for the transcutaneous electrochemical glucose sensor;
• and
• an electronics unit configured to provide calibrated glucose information, wherein the electronics unit has been programmed to calibrate data generated by the transcutaneous electrochemical glucose sensor using the stored calibration information without reliance on any reference glucose measurements made after insertion of the in vivo portion of the transcutaneous electrochemical glucose sensor into a host.

A glucose monitoring device comprising:

• a memory storing calibration information for a transcutaneous electrochemical glucose sensor, wherein the calibration information is derived at least in part from an empirically derived relationship between in vitro sensitivity and in vivo sensitivity;
• a processor generating calibrated glucose information, wherein the calibrated glucose information is based at least in part on applying the stored calibration information to data generated by the transcutaneous electrochemical glucose sensor, without reliance on any reference glucose measurements made after insertion of an in vivo portion of the transcutaneous electrochemical glucose sensor into a host;
• and
• a display providing the calibrated glucose information to a user.