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US 10,743,791 B2Granted
System and method for assessing tissue properties using magnetic resonance imaging
AssigneeWisconsin Alumni Research Foundation
InventorsScott B. Reeder, Roberta M. Strigel
Life of this patent
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Abstract
A system and method for assessing tissue properties of a subject within a region of interest (ROI) using a magnetic resonance imaging (MRI) system includes acquiring chemical-shift-encoded imaging data of the ROI. The method also includes determining, from imaging data a proton density water fraction (PDWF) map and quantifying, using the PDWF map, a property of tissue within the ROI. The method further includes generating, using the PDWF map, a report indicating the quantified property of the tissue. The tissue may include fibroglandular tissue (FGT).
Claims28
A method for assessing tissue properties of a subject within a region of interest (ROI) using a magnetic resonance imaging (MRI) system, the method including steps comprising:
- (i) acquiring chemical-shift-encoded imaging data of the ROI, wherein the ROI includes a breast of the subject;
- (ii) from the imaging data, determining a proton density water fraction (PDWF) map;
- (iii) using the PDWF map, quantifying a property of tissue within the ROI;
- (iv) determining a volume of the breast and a volume of fibroglandular tissue (FGT) in the breast;
- and
- (v) using the PDWF map and one of the volume of the breast or the volume of the FGT, generating a report indicating the quantified property of the tissue.
3 more elements
A method for assessing tissue properties of a subject within a region of interest (ROI) using a magnetic resonance imaging (MRI) system, the method including steps comprising:
- (i) acquiring chemical-shift-encoded imaging data of the ROI;
- (ii) from the imaging data, determining a proton density water fraction (PDWF) map;
- (iii) using the PDWF map, quantifying a property of tissue within the ROI;
- (iv) using the PDWF map, generating a report indicating the quantified property of the tissue;
- and
- wherein step (i) includes processing the chemical-shift-encoded imaging data using a region growing method to control water-fat swaps and create chemical-shift-encoded, water-fat separated data from the ROI.
3 more elements
A method for assessing tissue properties of a subject within a region of interest (ROI) using a magnetic resonance imaging (MRI) system, the method including steps comprising:
- (i) acquiring chemical-shift-encoded imaging data of the ROI;
- (ii) from the imaging data, determining a proton density water fraction (PDWF) map;
- (iii) using the PDWF map, quantifying a property of tissue within the ROI;
- (iv) using the PDWF map, generating a report indicating the quantified property of the tissue;
- and
- further comprising performing a thresholding of voxels containing predominantly adipose tissue to control for water content of adipose tissue in the ROI.
3 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- wherein the ROI includes a breast and wherein quantified property of the tissue includes a quantification of at least one of concentration or volume of fibroglandular tissue in the breast;
- and
- wherein the computer system is further programmed to determine a volume of the breast and a volume of fibroglandular tissue (FGT) in the breast.
9 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- and
- wherein the PDWF is free of errors cause by partial volume effects.
8 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- and
- wherein, to determine the PDWF, the computer system is further programmed to determine a proton density fat fraction (PDFF) and calculating PDWF as 1 minus PDFF.
8 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- and
- wherein the computer system is further programmed to process the chemical-shift-encoded data using a region growing method to control water-fat swaps and create at least one water-only image and at least one fat-only image.
8 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- and
- wherein the computer system is further programmed to use a mask to control influence of values in the PDWF map that include background noise.
8 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- and
- wherein the computer system is further programmed to perform a segmenting process to remove portions of the ROI that do not include the tissue.
8 more elements
A magnetic resonance imaging (MRI) system comprising:
- a magnet system configured to generate a polarizing magnetic field about at least a portion of a subject arranged in the MRI system;
- a plurality of gradient coils configured to apply a gradient field to the polarizing magnetic field;
- a radio frequency (RF) system configured to apply an excitation field to the subject and acquire MR image data from a ROI;
- a computer system programmed to:
- receive chemical-shift-encoded data of the ROI acquired using the RF system and gradient coils;
- analyze the chemical-shift-encoded data, to determine a water component and fat component;
- using the chemical-shift-encoded data, the water component, and the fat component, determine a proton density water fraction (PDWF) map;
- using the PDWF map, quantify a property of tissue within the ROI;
- using the PDWF map, generate a report indicating the quantified property of the tissue;
- and
- wherein the computer system is further programmed to perform a thresholding of voxels containing predominantly adipose tissue to control for water content of adipose tissue in the ROI.
8 more elements
Dependencies are inferred from the claim text.