Device and method to measure ventricular arterial coupling and vascular performance

A device for measuring a ventricular-arterial coupling of a subject, comprising:

• a first input for receiving signals from a plurality of electrocardiogram sensors that are coupled to the subject at a plurality of first locations;
• a second input for receiving signals from a plurality of photoplethysmogram sensors that are coupled to the subject at a plurality of second locations, wherein the second locations are selected from the group consisting of a head of the subject, an arm of the subject, and a leg of the subject, and wherein the signals received from the electrocardiogram sensors and the signals received from the photoplethysmogram sensors are received simultaneously;
• and
• a monitor configured to display the signals from the electrocardiogram sensors and the signals from the photoplethysmogram sensors, wherein the device is configured to measure:
• a time to arrival between a time at which an aortic valve of the subject opens to a pulse wave arrival at one or more of the second locations;
• and
• an ejection time, a delta ejection time, and an ejection time index of the subject, wherein the device is configured to determine that the ejection time is different in different parts of a vascular tree of the subject based at least partially upon the delta ejection time and the ejection time index.