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US 10,743,768 B2Granted
Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
AssigneeVisEn Medical, Inc.
InventorsWael Yared, Joshua Kempner, Jorge Ripoll Lorenzo, Alicia Arranz
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Abstract
In certain embodiments, the invention relates to systems and methods for in vivo tomographic imaging of fluorescent probes and/or bioluminescent reporters, wherein a fluorescent probe and a bioluminescent reporter are spatially co-localized (e.g., located at distances equivalent to or smaller than the scattering mean free path of light) in a diffusive medium (e.g., biological tissue). Measurements obtained from bioluminescent and fluorescent modalities are combined per methods described herein.
Claims16
A method for imaging a target region of a diffuse object, the method comprising:
- (a) administering a probe comprising a fluorescent species to the object, wherein following administration of the probe the fluorescent species is co-located with a bioluminescent reporter in the object;
- (b) detecting bioluminescent light emitted from the object by the bioluminescent reporter in the target region of the object;
- (c) directing excitation light into the object at multiple locations and/or at multiple angles, thereby exciting the fluorescent species;
- (d) detecting fluorescent light, the detected fluorescent light having been emitted by the fluorescent species in the target region of the object as a result of excitation by the excitation light;
- and
- (e) processing data corresponding to the detected bioluminescent light and the detected fluorescent light via tomographic reconstruction to provide a tomographic image of the target region of the object.
3 more elements
Dependencies are inferred from the claim text.