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US 10,738,306 B2Granted
Artificial nucleic acid molecules for improved protein or peptide expression
AssigneeCureVac AG
InventorAndreas Thess
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Abstract
The invention relates to an artificial nucleic acid molecule comprising at least one 5′UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and/or a 3′UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination.
Claims20
An artificial nucleic acid molecule comprising, from 5′ to 3′:
- a) at least one 5′-untranslated region element (5′UTR element) which comprises a nucleic acid sequence having an identity of at least 95% to a nucleic acid sequence according to any of SEQ ID NOs:
- 1368 and 1452-1458, or a corresponding RNA sequence, wherein the 5′UTR element lacks a 5′TOP motif;
- and
- b) at least one open reading frame (ORF),
- wherein the ORF is heterologous relative to the 5′UTR element.
2 more elements
Dependencies are inferred from the claim text.