Anti-tryptase antibodies, compositions thereof, and uses thereof
AssigneeGenentech, Inc.
InventorsXiaocheng Chen, Mark Dennis, Janet Jackman, James T. Koerber, Mason Lu, Henry R. Maun, Kathila Rajapaksa, Saroja Ramanujan, Tracy Staton, Lawren Wu, Tangsheng Yi
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Abstract
The invention provides compositions including anti-tryptase antibodies and pharmaceutical compositions thereof, as well as methods of using the same.
Claims45
An isolated nucleic acid, or a set of isolated nucleic acids, encoding an antibody that binds to human tryptase beta 1, or an antigen-binding fragment thereof, wherein the antibody comprises the following six hypervariable regions (HVRs):
- (a) an HVR-H1 comprising the amino acid sequence of DYGMV (SEQ ID NO:
- 7);
- (b) an HVR-H2 comprising the amino acid sequence of FISSGSSTVYYADTMKG (SEQ ID NO:
- 2);
- (c) an HVR-H3 comprising the amino acid sequence of RNYDDWYFDV (SEQ ID NO:
- 8);
- (d) an HVR-L1 comprising the amino acid sequence of SASSSVTYMY (SEQ ID NO:
- 4);
- (e) an HVR-L2 comprising the amino acid sequence of RTSDLAS (SEQ ID NO:
- 5);
- and
- (f) an HVR-L3 comprising the amino acid sequence of QHYHSYPLT (SEQ ID NO:
- 6).
An isolated nucleic acid, or a set of isolated nucleic acids, encoding an antibody that binds to human tryptase beta 1, or an antigen-binding fragment thereof, comprising (a) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 9 and (b) a VL domain comprising the amino acid sequence of SEQ ID NO:
- 10, wherein the nucleic acid or the set of nucleic acids comprises a sequence having at least 90% sequence identity to the sequence of SEQ ID NO:
- 104 and/or SEQ ID NO:
- 105.
An isolated nucleic acid, or a set of isolated nucleic acids, encoding an antibody that binds to human tryptase beta 1, or an antigen-binding fragment thereof, wherein the antibody comprises (a) a VH domain comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 9 and (b) a VL domain comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of SEQ ID NO:
- 10.
An isolated nucleic acid, or a set of isolated nucleic acids, encoding an antibody comprising (a) a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 76 or SEQ ID NO:
- 78 and (b) a light chain comprising the amino acid sequence of SEQ ID NO:
- 77.
Dependencies are inferred from the claim text.