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AssigneeMemorial Sloan Kettering Cancer Center
InventorsLiang Deng, Stewart Shuman, Jedd Wolchok, Taha Merghoub, Weiyi Wang, Peihong Dai, Ning Yang
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The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.
A composition comprising a recombinant modified vaccinia Ankara (MVA) virus, wherein the recombinant MVA comprises MVAΔE3L harboring hFlt3L (MVAΔE3L-hFlt3L).
A recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L) modified to express human Fms-like tyrosine kinase 3 ligand (hFlt3L).
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