US 10,736,944 B2 · Compositions for preventing or treating sepsis or septic shock compromising ADK protein as active ingredient

Abstract

The present invention relates to a composition for preventing or treating sepsis or septic shock including a Mycobacterium tuberculosis-derived adenosine kinase (ADK) protein as an active ingredient. The Mycobacterium tuberculosis-derived ADK protein according to one exemplary embodiment of the present invention has an effect of inhibit binding between the LPS and cells by binding to LPS, and also has an excellent therapeutic effect against sepsis by enhancing viability in a sepsis animal model and suppressing inflammatory response in the lung and cell death in the spleen.

Claims4

Dependent claims

A method for preventing or treating sepsis or septic shock, the method comprising administering an adenylate kinase (ADK) protein as an active ingredient in a subject in need thereof, wherein the ADK protein comprises a protein at least 95% identical to the amino acid sequence set forth in SEQ ID NO:

1, wherein the sepsis or septic shock is caused by infection with Staphylococcus sp., Streptococcus sp., Escherichia coli, Pseudomonas aeruginosa, Mycobacterium tuberculosis, Klebsiella pneumoniae, eumycetes, and/or anaerobic bacteria.

Dependencies are inferred from the claim text.

Facts

Application

16/120,603Filed 4 Sep 2018 · continuation

Priority

KR 10-2014-004857323 Apr 2014

Published

US 2019/0060418 A128 Feb 2019

Granted

11 Aug 2020

Term ends

Not estimatedThe source records don’t support an estimate.

Classification14 codes

A61K 38/45
Enzymes; Proenzymes; Derivatives thereof: transferases
A23L 29/06
Foods or foodstuffs containing additives ; Preparation or treatment thereof: enzymes
A61P 11/00
Drugs for disorders of the respiratory system
A61P 29/00
Non-central analgesic, antipyretic or antiinflammatory agents

Family

PCT/KR2014/006028Parent of this continuation · filed 7 Jul 2014

US 2019/0060418 A1Pre-grant publication · published 28 Feb 2019

Application14/414,366Parent of this continuation

US 2016/0263199 A1Published application

US 10,736,944 B2This patent

From the US filing history. Foreign family members aren’t listed.

Compositions for preventing or treating sepsis or septic shock compromising ADK protein as active ingredient

Life of this patent

Compositions for preventing or treating sepsis or septic shock compromising ADK protein as active ingredient

Life of this patent

Abstract

Claims4