Nylon-3 co-polymers and synthetic lung surfactant compositions containing same

An artificial lung surfactant composition comprising a polymer, wherein the polymer is a random copolymer comprising monomers, wherein the monomers comprise a first set of monomers and a second set of monomers, wherein:

• each monomer in the first set has a structure of:
• wherein one of R3, R4, R5, and R6 in each monomer in the first set is amino or amino-C1-C6-alkyl and three of R3, R4, R5, and R6 in each monomer in the first set are independently selected from the group consisting of hydrogen and methyl;
• and
• each monomer in the second set has a structure of:
• wherein:
• one of R3 and R4 combined with one of R5 and R6 in each monomer in the second set, together with the carbon atoms to which they are attached, define a cyclic moiety “A”
• A together with the carbon atoms to which it is attached is unsubstituted C8 cycloalkyl;
• and
• the other of R3 and R4 and the other of R5 and R6 in each monomer in the second set are hydrogen;
• the monomers of the first set and the monomers of the second set are present in the polymer in a proportion of from 1:2 to 2:1 (monomers of the first set:monomers of the second set);
• the first set of monomers and the second set of monomers are present in the polymer in a degree of polymerization of from about 16 to about 22;
• and
• the polymer yields:
• an average surface tension no higher than 35 mN m−1 with 0.40-mm radius bubbles composed of 1,2-diacyl-sn-glycero-3-phosphocholine (DPPC):1-palmitoyl-2-oleoyl-sn-glycero-3-[phospho-rac-(1-glycerol)]:palmitic acid (POPG):
• palmitic acid (PA) at a ratio of 68:22:9 (wt:wt:wt) within 5 minutes of exposure thereto at 37° C. in static-bubble mode of pulsating bubble surfactometry;
• a maximum average surface tension less than 45 mN m−1 and a minimum average surface tension less than 2 mN m−1 with 0.40-mm radius bubbles composed of DPPC:POPG:PA at a ratio of 68:22:9 (wt:wt:wt) at 5 minutes pulsation at 37° C. in dynamic-bubble mode of pulsating bubble surfactometry;
• an average percent surface area compression of less than 26.4% to reach a surface tension of 20 mN m−1 with 0.40-mm radius bubbles composed of DPPC:POPG:PA at a ratio of 68:22:9 (wt:wt:wt) at 5 minutes pulsation at 37° C. in dynamic-bubble mode of pulsating bubble surfactometry;
• or
• a combination thereof.